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xov xwm

Abstract

Melanoma tsuas yog muaj li 4% ntawm tag nrho cov qog nqaij hlav tawv tab sis yog ntawm cov mob qog nqaij hlav ntau. Dacarbazine yog cov tshuaj ntawm kev xaiv rau kev kho tus mob melanoma hauv Brazil los ntawm kev noj qab haus huv rau pej xeem feem ntau vim tias nws tus nqi qis. Txawm li cas los xij, nws yog alkylating tus neeg sawv cev ntawm qis qis tshwj xeeb thiab ua kom kho qhov lus teb hauv kev kho tsuas yog 20% ​​ntawm rooj plaub. Lwm yam tshuaj muaj nyob rau hauv kev kho mob ntawm melanoma yog kim, thiab cov qog nqaij hlav feem ntau tsim kho tsis haum rau cov tshuaj no. Kev sib ntaus tawm tsam melanoma xav tau cov tshuaj tshiab, ntau cov tshuaj tshwj xeeb uas ua kom tua tau cov tshuaj tiv thaiv qog noj ntshav. Dibenzoylmethane (1,3-diphenylpropane-1,3-dione) derivatives yog cog lus antitumor tus neeg sawv cev. Hauv txoj kev tshawb nrhiav no, peb tshawb xyuas cov txiaj ntsig cytotoxic ntawm 1,3-diphenyl-2-benzyl-1,3-propanedione (DPBP) ntawm B16F10 melanoma hlwb raws li nws cov kev cuam tshuam ncaj qha nrog cov DNA molecule uas siv optical tweezers. DPBP qhia tau cov txiaj ntsig zoo tiv thaiv qog hlwb thiab muaj qhov ntsuas tau xaiv ntawm 41.94. Tsis tas li ntawd, peb tau pom tias muaj peev xwm ntawm DPBP los cuam tshuam ncaj qha nrog DNA cov lej. Qhov tseeb tias DPBP tuaj yeem sib cuam tshuam nrog DNA hauv vitro tso cai rau peb kwv yees tias kev cuam tshuam zoo li no tseem yuav tshwm sim hauv vivo thiab, yog li, DPBP tuaj yeem yog lwm txoj hauv kev los kho cov neeg mob melanomas uas muaj tshuaj tiv thaiv. Cov kev tshawb pom no tuaj yeem coj los txhim kho cov tshuaj tshiab thiab zoo dua.

Duab kos duab

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Lub ntsiab lus ntawm feem pua ​​ntawm cov cell tuag tau rau DPBP compound tiv thaiv melan-A thiab B16F10 cov kab hauv ntau qhov sib txawv. Qhov xaiv cov ntsuas (SI = IC50 melan-A / IC50 B16F10) yog 41.94.                    

Luam tawm los ntawm Elsevier BV

Abstract

Dibenzoylmethane (DBM) yog cov kev sib txuam me me ntawm licorice thiab ib qho analog-diketone analogue ntawm curcumin. Kev pub noj 1% DBM hauv kev noj zaub mov rau Sencar cov nas thaum ob lub sijhawm pib thiab tom qab lub sijhawm pib muaj zog tiv thaiv 7,12-dimethylbenz [a] anthracene (DMBA) -induced mammary hlav ua ntau thiab cov qog nqaij hlav mammary los ntawm 97%. Txuas ntxiv hauv kev tshawb fawb vivo rau elucidate cov kev ua tau ntawm qhov muaj peev xwm tiv thaiv qhov kev txiav txim siab ntawm DBM, kev pub mis ntawm 1% DBM hauv AIN-76A kev noj haus kom tsis txaus rau Sencar nas rau 4-5 lub lis piam txo qis uterine ntub los ntawm 43%, inhibited tus nqi loj hlob ntawm mammary caj pas epithelial los ntawm 53%, uterine epithelium los ntawm 23%, thiab uterine stroma los ntawm 77%, thaum cov nas raug tua thaum thawj estrus theem ntawm estrous toog. Ib qho ntxiv, kev pub noj 1% DBM hauv kev noj haus rau Sencar nas ntawm 2 lub lis piam ua ntej, thaum lub sijhawm thiab 1 lub lis piam tom qab kho DMBA (kev tso tshuaj ntawm 1 mg DMBA rau nas ib zaug ib lub lim tiam rau 5 lub lis piam) inhibited tsim ntawm tag nrho DMBA – DNA ad ad hauv mammary cov qog los ntawm 72% siv post-32P-labeling assay. Yog li, pub mis rau 1% DBM kev noj haus rau Sencar cov nas tiv thaiv tsim kom muaj DMBA – DNA ua haujlwm hauv cov qog mammary thiab txo qis ntawm kev ua kom loj hlob ntawm cov qog mammary hauv vivo. Cov txiaj ntsig no yuav piav qhia txog qhov muaj zog tiv thaiv kev noj haus DBM ntawm kev muaj peev xwm ua tshuaj tua kab mob hauv cov nas tsuag.


Lub sij hawm tshaj tawm: Lub Yim Hli-12-2020